Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating
نویسندگان
چکیده
Citation Kasai, Kazue, Hiroshi Nakashima, Fang Liu, Samantha Kerr, Jiang Wang, Mitch Phelps, Philip M Potter, William B Goins, Soledad A Fernandez, and E Antonio Chiocca. 2013. “Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs.” Molecular Therapy. Nucleic Acids 2 (8): e113. doi:10.1038/mtna.2013.38. http://dx.doi.org/10.1038/mtna.2013.38.
منابع مشابه
Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs
MGH2.1 is a herpes simplex virus type 1 (HSV1) oncolytic virus that expresses two prodrug-activating transgenes: the cyclophosphamide (CPA)-activating cytochrome P4502B1 (CYP2B1) and the CPT11-activating secreted human intestinal carboxylesterase (shiCE). Toxicology and biodistribution of MGH2.1 in the presence/absence of prodrugs was evaluated in mice. MGH2.1 ± prodrugs was cytotoxic to human ...
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